Bespoke Biphasic Dissolution Paddle Catalogue PDF Part number 1401A00077 Biphasic Dissolution This dissolution is carried out in presence of two immiscible liquids, where lower layer is aqueous and upper layer is organic. As the API dissolves in the aqueous medium, it partitions in the organic layer based on its log P value. The organic layer acts as a reservoir to hold the dissolved drug. The API dissolution as well as partitioning can be deter-mined Applications *Used to overcome sink condition limitations that arise in conventional dissolution testing of poorly soluble API *Aids to discriminate between the excipient and manufacturing method *Predict concurrent dissolution and drug absorption *IVIVC establishment